This publication is a product of a regional collaboration involving eleven Ministries of Education in Southeast Asia (10 ASEAN Countries plus Timor Leste) working together on a framework to develop a Southeast Asia Teachers Competency Framework (SEA-TCF). The SEA-TCF is a set of skills, knowledge, behaviors, and attributes which the eleven Ministries of Education have agreed that teachers in their respective countries need to have. It consists of four essential competencies identified by key high officials from the eleven Ministries of Education as well as experts in teacher education from the 11 countries. The objective of the SEA-TCF is to serve as a guide for use in teacher professional development toward realizing 21st Century Skills and practices within a context that is regionally appropriate and in line with global best practices. Moreover, representatives from the eleven Ministries of Education agreed that the SEA-TCF can support the ASEAN Community and regional integration, as well as provide a solid foundation and guidelines for teacher exchange and teacher mobility within the Southeast Asia region.