This issue of the Development Research News (DRN) looks at the prospects, opportunities, and challenges facing the Philippines in the advent of the Fourth Industrial Revolution (FIRe). It summarizes the presentations and insights shared by local and foreign speakers who participated in the events led by the Philippine Institute for Development Studies during the month-long Development Policy Research Month in September. Likewise, it looks at the challenges confronting Muslim Mindanao, a poverty- and conflict-stricken region, in the face of new advancements in science and technology. The issue also features an article on the Internet of Things and how this technology can improve the Philippine manufacturing sector, as well as infographics on other frontier technologies of the FIRe.