Quality of life (QOL), composed of four domains (cognitive, emotional, social, and physical, is a recent focus of management of chronic diseases. This study primarily aimed to determine the relationship between parent’s knowledge about epilepsy, medication adherence, and quality of life among children with epilepsy. Although knowledge is high, misconceptions about the condition still exist. Adherence to the prescribed medication regimen was also poor. Cognitive, emotional, social, and overall QOL were high, but physical QOL was low. The overall QOL and social domain were influenced by both knowledge and adherence scores. With these findings, the QOL of CWEs must be given attention by healthcare practitioners and academic institutions.