The study aims to contribute to APEC's efforts in building lessons and literature in science and technology and in micro, cottage, and small and medium enterprises (SMEs). It describes selected research undertaken by research and development institutes (RDIs) of the Department of Science and Technology (DOST), the technologies developed and transferred to individuals and firms, the opportunities and constraints which technology adopters faced as they commercialized the technologies, and the participation of women and men in these endeavors. Policy initiatives may focus on strengthening collaborative work among the RDIs, academic institutions, and the private sector to ensure that the needs of the private sector are given full consideration in the development of R&D programs. This will result in a demand-driven policy thrust that will support the needs of the private sector, particularly the microenterprises and SMEs for technological innovation and services.