The advent of modern technology though the application of biotechnology on plants is a positive and innovative step in accelerating agricultural development. However, some compelling issues continue to hound the Department of Agriculture (DA) since the safety and acceptability of GMOs or genetically modified organisms related to economic, health, moral and environmental impact are a paramount concern to consumers, small farmers and fisherfolk, as well. The paper presents the government's policies on GMOs including current efforts on the promotion of safe and responsible application of modern biotechnology in the country.