Mindanao today stands at the nexus of peace, productivity, and transformation. Decades back, the island was regarded in the lens of struggle and underdevelopment, now the island emerges as a decisive contributor to national progress. With ₱3.8 trillion in economic output in 2024 contributing 17.1% to the Philippine economy’s wealth, and home to 27.4 million people, Mindanao fortifies its role as the country’s food basket, investment frontier, logistics corridor, and an emerging significant contributor to the national development. The past years have shown that when peace is sustained and nurtured, institutions flourished resulting in acceleration of economic activities in various levels. Across regions, the BARMM, Davao, Northern Mindanao, SOCCSKSARGEN, Caraga, and Zamboanga Peninsula, the growth story is similar which is characterized by rising production, market expansion, expanding total factor productivity, improving mobility and transportation, and the overall public confidence at historic highs. Mindanao’s transformation is not incidental; it is a result of achieving stability, improved governance, and the collective aspirations of communities. This paper presents an integrated view of Mindanao’s economic landscape, the gains and persistent bottlenecks, and the strategic direction to move the island towards inclusive, innovation-driven development.