This paper, adapted from the first episode of The Katipunan Dialogue Podcast Season 5, analyzes the anticipated trajectories and implications of "Trump 2.0" foreign policy. The study explores the potential return of "America First" unilateralism and its disruptive effects on global alliances, international trade agreements, and multilateral institutions. Key discussions center on the shift toward transactional diplomacy, the heightening of US–China strategic competition, and the specific security and economic anxieties faced by Southeast Asian nations, including the Philippines. By synthesizing expert commentary on geopolitical shifts, the research evaluates how a second Trump administration might redefine American engagement in the Indo-Pacific and beyond. Ultimately, the paper underscores the need for regional actors to develop more autonomous and resilient foreign policies to navigate an era of increased American unpredictability and global strategic volatility.