This study investigates semantic comparison between Davao and Cebu varieties of Binisaya focusing on the potential L1-L2 interference. There were 25 synonymous words from both varieties designed for a classroom writing task. Findings revealed that 68% of the lexical items exhibit semantic alignment, leading to the assumption of cross-dialectical intelligibility due to shared Austronesian roots. However, 32% of entries demonstrate semantic mismatches, which reflected Lado’s Contrastive Analysis Hypothesis, that linguistic differences between native and target language pose learning challenges. These mismatches are not arbitrary but culturally and regionally situated. The study concludes that semantic variation within the two varieties can lead to misinterpretation and communicative friction if not addressed pedagogically. By applying this contrastive approach, educators can better diagnose learner difficulties and design culturally responsive instruction that accounts regional vocabulary.