The CALABARZON Harmonized Regional Research and Development Agenda (HRRDA) 2023–2028 serves as a strategic guide for aligning research, development, and innovation (RDI) initiatives with the region’s priority development needs. Anchored on the CALABARZON Regional Development Plan 2023–2028 and AmBisyon Natin 2040, the agenda aims to promote economic and social transformation toward a prosperous, inclusive, and resilient region. It harmonizes research efforts across government, academe, and industry to ensure that studies generate practical, market-driven, and socially relevant outputs.