In every work environment, it is important to identify risk factors that may contribute to the development of occupational disorders. This study aimed to analyze the work system of a local garment factory’s trimming department and to minimize the risk of developing musculoskeletal disorders (MSDs) among workers. The study involved ergonomic assessment wherein the proponents performed job worksite analysis, anthropometric analysis and utilized ergonomic tools such as Body Discomfort Chart (BDC) and Rapid Entire Body Assessment (REBA). This was used to identify the body segments with high degree of perceived discomfort that eventually may lead to work-related disorders. Then, the study developed ergonomic interventions to mitigate the development of MSDs. Lastly, evaluation using postural analysis to simulate the new working posture of the trimmers in improved workplace design was done. The result showed mismatch between workplace design and anthropometric measurements that resulted to strong perceived body discomfort (p = 0.001) predominantly in lower back, shoulder and calf. Assessment indicated medium to high risk exposure to MSDs and implied that change in work system is required immediately (p = 0.000). Ergonomic interventions recommended improvement on workplace design components, which comprised of sitting-standing working position, a chair that every worker would fit in with an adjustable height from 57 - 63 cm (22.44 - 24.80 in) and an adjustable forward-tilting seat up to 15° to address lumbar area problems. The ergonomic solutions involved application of Anthropometry and Occupational Biomechanics guidelines in order to fit the work systems elements to the workers and to maintain the neutral working positions of trimmers.